February 26, 2007

New Citations

A. Antigen-specific T-lymphocyte function after cord blood transplantation.
Elegant data indicating that T lymphocytes present in the HSC inoculum can contribute to the generation of antigen-specific T-lymphocyte immunity early after transplantation. See Annotated Bibliography XIII. Immune Reconstitution, Citation #6

B. Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies.
The title is misleading because this is an extensive review (26 pages) which must be read in the original because it is too comprehensive to be well summarized here so that only an outline can be provided. See Annotated Bibliography XIV. Stem Cell Plasticity and Regenerative Medicine, Citation #9

C. Hepatic injury following reduced intensity unrelated cord blood transplantation for adult patients with hematological diseases.
Liver injury is a common complication in allogeneic hematopoietic stem cell transplantation. See Annotated Bibliography XIV. section v. Adverse Events in Cord Blood Transplantation, Miscellaneous, Citation #3

D. Ex-vivo expansion does not alter the capacity of umbilical cord blood CD34+ cells to generate functional T lymphocytes and dendritic cells. Data indicating that ex-vivo expansion of CD34(+) cells does not impair T lymphopoiesis nor DC differentiation capacity. See Annotated Bibliography XVIII. Ex-Vivo Expansion of Hematopoietic Progenitor Cells, Citation #2

E. Submyeloablative cord blood transplantation corrects clinical defects seen in IPEX syndrome.
IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked) is a disorder of regulatory T-cell function, which can be associated with a fatal outcome early in life, although mixed results have been obtained with HSCT. See Annotated Bibliography VII, section ii. Cord Blood Transplantation in Children, Congenital Disorders, Citation #17.