The highlight of this site is the extensive, frequently-updated annotated bibliography on over 20 major subject areas, with multiple sub-categories. For a complete list of categories, click HERE or on Annotated Bibliography flyout message in the main menu on the left. For new items, click on the links in blue below.

AN ANNOTATED SUMMARY OF ABSTRACTS RELATING TO CORD BLOOD TRANSPLANTATION THAT WERE PRESENTED AT THE BMT TANDEM MEETINGS FEBRUARY 13-17, 2008 IN
SAN DIEGO, CALIFORNIA.

See Category XI, Recent Cord Blood Transplantation Conferences, Citation II:

1. Data on chronic GVHD (2 abstracts)
• Data indicating that cGVHD is more frequent and more resistant to immune-suppression therapy using PBSC vs BM.
• A comparison of outcomes using bone marrow (BM) or umbilical cord (UCB) as stem cell source in children which indicated that UCB patients have less chronic GVHD.
[These abstracts could suggest that UCB transplants should be utilized to avoid cGVHD, especially in comparison to PBSC transplants.]

2. Characterization of acute graft-versus-host disease (GVHD) in unrelated cord blood transplantation (UCBT).

3. Unrelated cord blood transplantation in adults with lymphoid malignancies.

4. A study of double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis indicating that the risk of acute and chronic GVHD are low when sirolimus and tacrolimus are used as GVHD prophylaxis.

5. The feasibility of using CCR5Δ32/Δ32 hematopoietic stem cell transplants for immune reconstitution in HIV-infected children.

6. The use of UCBT in congenital disorders (4 abstracts).
• Outcomes of HLA identical related CBT and BMT in patients with beta-thalassemia or sickle cell disease.
• UCBT for transfusion-dependent thalassemia.
• Unrelated UCBT congenital childhood diseases.
• UCBT in 159 young patients with peroxisomal and lysosomal storage disorders.

7. Improved outcome for transplantation of pediatric patients with non-malignant disorders with unwashed plasma depleted cord blood (PD CB).

8. Unrelated UCBT after myeloablative conditioning in 98 adult patients with acute leukemia.

9. A novel method to reduce rates of extensive cGVHD without increased relapse for UCBT.

10. A analysis of risk factors associated with graft failure, outcomes following UCBT for Hurlers syndrome and chronic GVHD. (3 abstracts).

Recent New Categories and New Citations

• April 30, 2008

• March 17, 2008