12. History of the clinical use of umbilical cord blood hematopoietic cells. Gluckman E, Rocha V. Cytotherapy. 2005;7:219-27.

This is an interesting review by experienced authors.

The first cord blood (CB) transplant was performed in 1988 in a patient with Fanconi anemia. The donor was his HLA-identical sister who was known by pre-natal diagnosis to be HLA identical and not affected by the Fanconi mutation. The CB was collected and cryopreserved at birth. The transplant was successful without GVHD and the patient is currently alive and free of disease more than 15 years after transplant, with full hematologic and immunologic donor reconstitution. Since that first CB transplant, more than 5,000 cases have been reported world-wide.

The authors review the experimental background that was necessary prior to the first CB transplant. Since the first transplant, many questions have been answered but others are still open for further research. The review considers the development of knowledge regarding such topics as GVHD, graft-versus leukemia, immune reconstitution, cord blood banking, and the place of CB transplant compared with other sources of HSC.

13. Symposium Proceedings: Third Annual International Umbilical Cord Blood Transplantation Symposium, Los Angeles, June 3-4, 2005.

A summary of the 3rd Annual Symposium and Abstracts of the presentations were published in the November 2005 issue of Biology of Blood and Marrow Transplantation (2005;11:921-939).

The Symposium faculty consisted of 23 speakers from the United States, Italy, France, Spain, Germany, and Japan. The program was divided into 7 sessions: (I) unrelated donor cord blood transplantation in adults, (II) practical aspects of cord blood transplantation, (III) optimal supportive care in cord blood transplantation, (IV) cord blood transplantation for childhood/genetic disorders, (V) immune status after cord blood transplantation, (VI) ex vivo expansion and regenerative medicine, and (VII) contemporary issues in cord blood banking.

The authors of abstracts include Cladd Stevens, Pablo Rubinstein, John Wagner, Juliet Barker, Satoshi Takahashi, Eliane Gluckman, Guillermo Sanz, Mary Laughlin, Effie Petersdorf, Lee Ann Baxter-Lowe, Joanne Kurtzberg, Marco Zecca, Franco Locatelli, Mark Walters, Bruce Blazar, Kenneth Weinberg, Elizabeth Shpall, Catherine Verfaillie, Peter Wernet, Michael Creer and Ellen Lazarus.

Program details are listed at : www.cordbloodsymposium.org/la_2005/index.html.

The 4th Annual International Umbilical Cord Blood Transplantation Symposium was held in Los Angeles May 19-20, 2006.

The 34 member faculty for the Symposium included leaders of the major transplant centers from around the globe. Attendees were from Japan, New Zealand, Australia, Singapore, France, the UK, Israel, Mexico, Colombia, Ecuador, Chile, Brazil, Venezuela, Argentina, Malaysia, India, Sweden, Italy, Spain, Slovak Republic, Taiwan, Saudi Arabia, the UAE, Kuwait, Greece, Netherlands, Canada, China, Hong Kong, Korea, Thailand and from across the USA.

Program details are listed at: www.cordbloodsymposium.org/la_2006/program.html

A summary of the Symposium and Abstracts of the presentations were published in Biology of Blood and Marrow Transplantation. 2006 Nov;12(11):1206-27.

The 5th Annual International Umbilical Cord Blood Transplantation Symposium was held in Los Angeles on May 11-12, 2007. Program details are listed at: www.cordbloodsymposium.org/la_2007/program.html. The Summary and Abstracts of the have been published: Biology of Blood and Marrow Transplantation 2007;13(11):1380-92. Reprints are still available. To receive a reprint, send your postal mailing address to: symposiumreprint@cordbloodforum.org

Please click HERE for more information on all past symposia. The 2008 Symposium will be held in Los Angeles on June 6-7, 2008. Click HERE for details.

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